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Related Concept Videos

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Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
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Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
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Lead Phytochemicals for Anticancer Drug Development.

Sukhdev Singh1, Bhupender Sharma1, Shamsher S Kanwar1

  • 1Department of Biotechnology, Himachal Pradesh University Shimla, India.

Frontiers in Plant Science
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

Plant-derived bioactive phytochemicals show promise as effective anticancer therapies with minimal side effects. Research focuses on their mechanisms against cancer cell signaling and clinical development for novel cancer treatments.

Keywords:
anticancer phytochemicalscancerdruggability evaluationlimitations of anticancer drugs

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Area of Science:

  • Pharmacology and Drug Discovery
  • Natural Product Chemistry
  • Oncology

Background:

  • Cancer remains a leading cause of mortality despite existing treatments.
  • There is a critical need for novel anticancer therapies with improved efficacy and reduced side effects.
  • Phytochemicals, compounds from plants, are emerging as promising candidates for cancer treatment due to their targeted action.

Approach:

  • This review explores lead phytomolecules with anticancer properties.
  • It details their mechanisms of action on nuclear and cellular factors in carcinogenesis.
  • Druggability and clinical development of these anticancer phytomolecules are also discussed.

Key Points:

  • Bioactive phytochemicals exhibit selective toxicity towards cancer cells, sparing normal cells.
  • Their pleiotropic functions allow them to target multiple signaling pathways involved in carcinogenesis.
  • Numerous phytochemicals demonstrate anticancer activity in both in vitro and in vivo studies.

Conclusions:

  • Phytochemicals represent a viable source for developing novel, side-effect-free anticancer drugs.
  • Understanding their mechanisms of action is crucial for advancing their clinical application.
  • Further research into druggability and clinical trials will facilitate the translation of these natural compounds into cancer therapies.