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Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

Magnetic-, Acoustic-, and Optical-Triple-Responsive Microbubbles for Magnetic Hyperthermia and Pothotothermal Combination Cancer Therapy

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Core-Shell Nanostars for Multimodal Therapy and Imaging.

Mengyuan Li¹, Lele Li¹, Changyou Zhan¹

¹Laboratory for Biomaterials and Drug Delivery, Department of Anesthesiology, Division of Critical Care Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA, 02115. Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge MA 02139, USA.

|November 24, 2016

Summary

This summary is machine-generated.

Researchers created multifunctional nanoparticles that combine diagnostic imaging and cancer therapy. These gold nanostar-based nanoparticles offer photothermal therapy, chemotherapy, and MRI/TPL imaging for enhanced tumor treatment and monitoring.

Keywords:

gold nanostar imaging

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Area of Science:

Biomedical Engineering
Nanotechnology
Materials Science

Background:

Developing multifunctional nanomedicine for simultaneous diagnosis and therapy is a significant challenge.
Integrating diagnostic capabilities with therapeutic delivery enhances treatment efficacy and monitoring.

Purpose of the Study:

To engineer multifunctional nanoparticles (AuNS@CP) combining diagnostic imaging (MRI, TPL) and therapeutic functions (photothermal therapy, chemotherapy).
To evaluate the in vivo efficacy of these nanoparticles for cancer treatment and monitoring.

Main Methods:

Fabrication of gold nanostar (AuNS) core nanoparticles coated with a metal-drug coordination polymer (CP) shell containing gadolinium and gemcitabine monophosphate.
Characterization of nanoparticle properties, including T1 contrast for MRI and two-photon photoluminescence (TPL) for imaging.
In vivo evaluation of nanoparticle localization via MRI and intravital TPL imaging.
Assessment of combined photothermal therapy and chemotherapy efficacy in inhibiting tumor growth.

Main Results:

AuNS@CP nanoparticles demonstrated strong T1 contrast for MRI-based in vivo localization.
Intravital TPL imaging allowed microscopic observation of nanoparticle behavior within tumors.
The combined photothermal and chemotherapeutic effects significantly inhibited tumor growth in vivo.

Conclusions:

The developed AuNS@CP nanoparticles represent a promising multifunctional nanomedicine platform for integrated cancer diagnosis and therapy.
This approach enables noninvasive monitoring of nanoparticle distribution and effective tumor suppression through combined treatment modalities.