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Chemically engineered persistent luminescence nanoprobes for bioimaging.

Thomas Lécuyer1, Eliott Teston1, Gonzalo Ramirez-Garcia1

  • 1Unité de Technologies Chimiques et Biologiques pour la Santé (UTCBS), UMR 8258 CNRS, U 1022 Inserm, Université Paris Descartes, Sorbonne Paris Cité, Faculté des Sciences Pharmaceutiques et Biologiques, 75006 Paris, France.; Chimie-ParisTech, PSL, 75005 Paris, France.

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This review explores persistent luminescence nanoprobes for advanced bioimaging. These engineered nanoparticles offer enhanced contrast for early disease detection and treatment monitoring in preclinical studies.

Keywords:
Nanoparticleschemistrypersistent luminescence and in vivo imaging.surface coating

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Optical Imaging

Background:

  • Imaging nanoprobes enhance contrast in bioimaging.
  • Optical sensors are crucial for cellular and molecular-level biological event tracking.
  • Nanoprobe optical properties are tunable via composition, size, and surface engineering.

Purpose of the Study:

  • To review research on nanoprobes with persistent luminescence properties.
  • To highlight their application as potent bioimaging agents.
  • To focus on their use in preclinical assays.

Main Methods:

  • Focus on the design and synthesis of nanoprobes.
  • Engineering of nanoprobe composition, size, and surface.
  • Evaluation of persistent luminescence properties.
  • Application in preclinical bioimaging.

Main Results:

  • Nanoprobe optical properties can be precisely controlled.
  • Persistent luminescence nanoprobes demonstrate significant potential for bioimaging.
  • Successful application in preclinical settings.

Conclusions:

  • Persistent luminescence nanoprobes represent a promising advancement in bioimaging.
  • Their tunable optical properties enable sophisticated diagnostic and monitoring capabilities.
  • Further preclinical research is warranted to translate this technology.