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Related Concept Videos

Site-Targeted Drug Delivery Systems: Polymeric Carriers01:24

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Polymeric carriers enhance targeted drug delivery by increasing efficacy while minimizing off-target effects. These carriers comprise a biodegradable polymeric backbone integrated with functional elements that enable targeting, improve physicochemical properties, and regulate drug release.Targeting MechanismsThe targeting ability of polymeric carriers is mediated by a homing device, which is a molecular recognition component designed to selectively bind to specific tissues or cells. Monoclonal...
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Biopolymeric nanoparticles.

Sushmitha Sundar1, Joydip Kundu1, Subhas C Kundu1

  • 1Department of Biotechnology, Indian Institute of Technology, Kharagpur 721302, India.

Science and Technology of Advanced Materials
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

This review explores biocompatible nanoparticles made from natural biopolymers like proteins and polysaccharides. It details fabrication methods, characterization techniques, and applications in medicine and biotechnology.

Keywords:
applicationsbiopolymerfabricationnanoparticlespolysaccharidesproteins

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Polymer Chemistry

Background:

  • Biopolymers, including proteins and polysaccharides, are increasingly utilized in developing advanced nanomaterials.
  • Natural biopolymers offer biocompatibility and biodegradability, crucial for biomedical applications.
  • Nanoparticles fabricated from these biopolymers are revolutionizing materials science.

Approach:

  • This review synthesizes recent advancements in biopolymer nanoparticle fabrication.
  • It details key manufacturing techniques such as emulsification, desolvation, coacervation, and electrospray drying.
  • The review outlines essential characterization methods for evaluating nanoparticle properties.

Key Points:

  • Fabrication methods for biopolymer nanoparticles are described, enabling tailored material properties.
  • Comprehensive characterization techniques are presented, covering particle size, surface charge, morphology, stability, and structure.
  • Crucial biological assessments including cellular uptake, cytotoxicity, drug loading, and drug release are detailed.

Conclusions:

  • Biopolymer nanoparticles demonstrate significant potential in medicine and biotechnology.
  • Further research into these natural nanomaterials promises innovative therapeutic and diagnostic solutions.
  • The review highlights a promising future scope for biopolymer-based nanotechnology.