Preparation and characterization of multifunctional magnetic mesoporous calcium silicate materials

We have prepared multifunctional magnetic mesoporous Fe-CaSiO₃ materials using triblock copolymer (P123) as a structure-directing agent. The effects of Fe substitution on the mesoporous structure, in vitro bioactivity, magnetic heating ability and drug delivery property of mesoporous CaSiO₃ materials were investigated. Mesoporous Fe-CaSiO₃ materials had similar mesoporous channels (5-6 nm) with different Fe substitution. When 5 and 10% Fe were substituted for Ca in mesoporous CaSiO₃ materials, mesoporous Fe-CaSiO₃ materials still showed good apatite-formation ability and had no cytotoxic effect on osteoblast-like MC3T3-E1 cells evaluated by the elution cell culture assay. On the other hand, mesoporous Fe-CaSiO₃ materials could generate heat to raise the temperature of the surrounding environment in an alternating magnetic field due to their superparamagnetic property. When we use gentamicin (GS) as a model drug, mesoporous Fe-CaSiO₃ materials release GS in a sustained manner. Therefore, magnetic mesoporous Fe-CaSiO₃ materials would be a promising multifunctional platform with bone regeneration, local drug delivery and magnetic hyperthermia.