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Updated: Mar 11, 2026
Surface Enhanced Raman Spectroscopy Detection of Biomolecules Using EBL Fabricated Nanostructured Substrates
Published on: March 20, 2015
Tunable and highly reproducible surface-enhanced Raman scattering substrates made from large-scale nanoparticle
Xiaoyan Liu1, Kenji Kitamura2, Qiuming Yu3
1College of Metallurgy and Materials Engineering, Chongqing University of Science and Technology, Chongqing 401331, People's Republic of China; Department of Material Science and Engineering, University of Washington, Seattle, WA 98195, USA.
Abstract:
This work describes novel surface-enhanced Raman scattering (SERS) substrates based on ferroelectric periodically poled LiNbO3 templates. The templates comprise silver nanoparticles (AgNPs), the size and position of which are tailored by ferroelectric lithography. The substrate has uniform and large sampling areas that show SERS effective with excellent signal reproducibility, for which the fabrication protocol is advantageous in its simplicity. We demonstrate ferroelectric-based SERS substrates with particle sizes ranging from 30 to 70 nm and present tunable SERS effect from Raman active 4-mercaptopyridine molecules attached to AgNPs when excited by a laser source at 514 nm.
