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Published on: May 22, 2018
Inhibition of Alzheimer amyloid β aggregation by polyvalent trehalose
Yoshiko Miura1, Chouga You2, Reiko Ohnishi3
1School of Materials Science, Japan Advanced Institute of Science and Technology, 1-1 Asahidai,Nomi, Ishikawa 923-1292, Japan; Department of Molecular Design and Engineering, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan.
Abstract:
A glycopolymer carrying trehalose was found to suppress the formation of amyloid fibrils from the amyloid β peptide (1-42) (Aβ), as evaluated by thioflavin T assay and atomic force microscopy. Glycopolymers carrying sugar alcohols also changed the aggregation properties of Aβ, and the inhibitory effect depended on the type of sugar and alkyl side chain. Neutralization activity was confirmed by in vitro assay using HeLa cells. The glycopolymer carrying trehalose strongly inhibited amyloid formation and neutralized cytotoxicity.
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