A low-cost method for chromoendoscopy for surveillance in ulcerative colitis

Area of Science:

• Gastroenterology
• Oncology

Background:

• Long-standing ulcerative colitis (UC) in Indian patients presents a significant risk for colorectal cancer (CRC).
• The incidence of CRC in this population mirrors that observed in Western countries, necessitating vigilant surveillance strategies.

Purpose of the Study:

• To evaluate the utility of chromoendoscopy-guided biopsy in dysplasia surveillance for Indian patients with long-standing ulcerative colitis.
• To present an economical method for performing chromoendoscopy, aiming to facilitate its widespread adoption.

Main Methods:

• The study details the experience with chromoendoscopy technique.
• An economical method involving reconstitution of indigo carmine from powder form is described and compared to commercial dyes.

Main Results:

• Chromoendoscopy-guided biopsy is highlighted as an important tool for detecting dysplasia in ulcerative colitis patients.
• Reconstituting indigo carmine from powder is presented as a cost-effective alternative, potentially improving accessibility.

Conclusions:

• Dysplasia surveillance is critical for Indian patients with long-standing ulcerative colitis due to high CRC risk.
• Economical chromoendoscopy using reconstituted indigo carmine can potentially become the standard of care for dysplasia surveillance nationwide.