Review article: mesenchymal stromal cell therapy for inflammatory bowel diseases
C Grégoire1, C Lechanteur2, A Briquet2
1Unit of Haematology, Department of Haematology, CHU of Liège, GIGA-I3, University of Liège, Liège, Belgium.
Alimentary Pharmacology & Therapeutics
|November 24, 2016
Summary
Mesenchymal stromal cells (MSCs) show promise for treating inflammatory bowel diseases (IBD), particularly Crohn's disease. While effective for fistulas, further research is needed to optimize MSC therapy for broader IBD applications.
Area of Science:
- Immunology
- Gastroenterology
- Regenerative Medicine
Background:
- Inflammatory bowel diseases (IBD) involve chronic intestinal inflammation and tissue damage.
- Mesenchymal stromal cells (MSCs) possess immunomodulatory and tissue repair capabilities.
Purpose of the Study:
- To review existing data on mesenchymal stromal cell (MSC) therapy for inflammatory bowel diseases (IBD).
Main Methods:
- Searched PubMed and ClinicalTrials.gov for studies on MSCs and IBD.
- Included terms like 'mesenchymal stem cell transplantation', 'Crohn disease', and 'ulcerative colitis'.
- Reviewed reference lists of identified publications.
Main Results:
- MSCs modulate immune cells (e.g., inhibiting Th1/Th17, recruiting regulatory T cells) and promote epithelial repair.
- Over 200 patients with refractory IBD fistulas showed significant response rates with local MSC injections.
- Systemic MSC infusions for Crohn's disease yielded promising results, especially with allogeneic MSCs, achieving remission in about 40%.
Conclusions:
- Mesenchymal stromal cell (MSC) therapy holds potential for treating IBD, especially Crohn's disease.
- Optimal MSC source, dosage, and administration require further investigation.
- Randomized controlled trials are necessary to compare MSC effectiveness against standard IBD treatments.
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