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Dynamin Functions and Ligands: Classical Mechanisms Behind.

Mahaveer Singh¹, Hemant R Jadhav², Tanya Bhatt²

¹Department of Pharmacy, Birla Institute of Technology and Sciences Pilani, Pilani Campus, Rajasthan, India mahaveer2singh@gmail.com.

Molecular Pharmacology

|November 24, 2016

Summary

This summary is machine-generated.

Dynamin, a GTPase, is crucial for cellular processes like endocytosis and organelle division. Its dysfunction is linked to numerous diseases, highlighting its therapeutic potential.

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Area of Science:

Biochemistry
Cell Biology
Molecular Medicine

Background:

Dynamin is a GTPase essential for clathrin-dependent endocytosis and vesicular trafficking.
It functions as molecular scissors in vesicle formation and is involved in organelle division, viral resistance, and mitochondrial dynamics.
Dynamin's role extends to phagocytosis and mitochondrial fusion/fission.

Purpose of the Study:

To review dynamin's mechanisms in various human disorders.
To guide medicinal chemists in designing novel dynamin ligands for therapeutic development.

Main Methods:

Literature review of dynamin's function and involvement in disease pathophysiology.
Analysis of dynamin-related mechanisms in neurological, cardiovascular, and other conditions.

Main Results:

Dynamin dysfunction is implicated in Alzheimer's, Parkinson's, Huntington's, and Charcot-Marie-Tooth diseases.
It is also linked to heart failure, schizophrenia, epilepsy, cancer, dominant optic atrophy, osteoporosis, and Down's syndrome.
The review details dynamin's multifaceted roles in cellular processes and disease.

Conclusions:

Understanding dynamin's role in disease is key for developing targeted therapies.
Novel dynamin ligands could offer new treatment strategies for a wide range of dynamin-related disorders.