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Updated: Mar 11, 2026

Author Spotlight: Creating a Versatile Experimental Autoimmune Encephalomyelitis Model Relevant for Both Male and Female Mice
Published on: October 13, 2023
Herpes simplex type 2 encephalitis and methotrexate medication: a fortuitous or causative association in a patient
Julien Lupo1,2, Ophélie Dos Santos3, Raphaele Germi1,2
1Laboratory of Virology, University Hospital of Grenoble, Grenoble, France.
Abstract:
It is unclear whether immunosuppression is a risk factor for herpes encephalitis. Herein, we describe a rare case of herpes simplex virus type 2 encephalitis in a patient treated with low-dose methotrexate for HLA-B27-associated spondyloarthritis. The patient was successfully treated with acyclovir but presented sequelae of encephalitis. Here we discuss the possible role of low-dose methotrexate therapy as a risk factor of neurological herpes reactivation and severe disease. The host-related and viral risk factors are also addressed.
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