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Updated: Mar 11, 2026

In Vitro Thrombosis Test for Ventricular Assist Devices
Published on: March 21, 2025
The AngioVac Device: Understanding the Failures on the Road to Success
Berhane Worku1, Arash Salemi, Marcus D DʼAyala
1From the *Department of Cardiothoracic Surgery, New York Methodist Hospital, Brooklyn, NY USA; †Department of Cardiothoracic Surgery, Weill Cornell Medical Center, New York Presbyterian Hospital, New York, NY USA; and ‡Division of Vascular Surgery, New York Methodist Hospital, Brooklyn, NY USA.
Insights
The AngioVac device effectively removes intact thrombus from the iliac, caval, and heart regions, offering a successful alternative to surgery. However, its efficacy is lower for pulmonary emboli, necessitating careful patient selection for optimal outcomes.
Area of Science:
- Vascular Surgery
- Interventional Cardiology
- Medical Devices
Background:
- Percutaneous thromboembolectomy often requires thrombus fragmentation and thrombolysis, increasing risks of bleeding and thromboembolic complications.
- The AngioVac device provides a percutaneous venovenous bypass to aspirate intact thrombus, potentially mitigating these risks.
Purpose of the Study:
- To review the literature on the AngioVac device.
- To identify factors correlating with successful thrombus extraction using the AngioVac system.
Main Methods:
- A literature search was conducted using the PubMed database for studies on the AngioVac device.
- Twenty-three reports detailing 57 procedures in 56 patients were analyzed.
Main Results:
- Complete thrombus removal was achieved in 75% of cases.
- Success rates were high for iliocaval thrombus (87%) and right heart thrombus (82%).
- Pulmonary emboli showed a significantly lower success rate (12.5%), with overall complications occurring in 12% of procedures.
Conclusions:
- The AngioVac device is a viable alternative to surgical thrombectomy for iliocaval and intracardiac thrombus.
- Patient selection is crucial for improving outcomes, particularly as pulmonary emboli appear less amenable to this technique.
- Further research with larger patient cohorts is needed to solidify these findings.
Objective:
Current percutaneous thromboembolectomy techniques may obviate surgical intervention in high-risk patients with iliocaval thrombus or thrombus of the right side of the heart, but typically require thrombus fragmentation and thrombolysis with associated bleeding and thromboembolic complications. The AngioVac (Angiodynamics, Latham, NY USA) device uses a percutaneous venovenous bypass circuit to aspirate intact thrombus. A review of the literature was performed with regard to the AngioVac device to determine the factors correlating with successful thrombus extraction.
Methods:
A literature search was performed with regard to use of the AngioVac device using the PubMed database. A meta-analysis was not performed given the small size and lack of statistical analysis of the individual reports included.
Results:
Twenty-three reports describing 57 procedures in 56 patients were analyzed. Indications for thrombectomy included iliocaval thrombus in 53% (30), thrombus of the right side of the heart, in 49% (28), pulmonary embolus in 14% (8), and upper extremity venous/Glenn shunt thrombosis in 7% (4). The complete success rate, defined as removal of all thrombus, was 75% (43), with an 11% (6) partial success rate. In 14% (8) of cases, minimal or no thrombus was retrieved. When analyzed by indication, iliocaval thrombus and thrombus of the right side of the heart demonstrated 87% (26) and 82% (23) complete success rates, respectively. Pulmonary embolus demonstrated a significantly lower success rate at 12.5% [1; (P < .001)]. Complications occurred in 12% (7), including six hematomas and one retroperitoneal bleed.
Conclusions:
The AngioVac device offers an excellent alternative to surgical thrombectomy for patients presenting with iliocaval or intracardiac thrombus, with success rates of more than 80%, although it seems that pulmonary emboli are less amenable. Appropriate patient selection can lead to improved outcomes. Larger numbers are needed to make more definite conclusions.
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