Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

<i>Ex vivo</i> and <i>in vivo</i> evaluation of an <i>in situ</i> nanogel composite loaded with carmustine: implications for efficient nose-to-brain delivery.

Pharmaceutical development and technology·2025
Same author

Script Shift: South African pharmacists' knowledge and perspectives of e-prescribing.

Health policy and planning·2025
Same author

Design Characteristics of a Neoteric, Superhydrophilic, Mechanically Robust Hydrogel Engineered To Limit Fouling in the Ocular Environment.

ACS omega·2024
Same author

Advances in Translational Nanotechnology: Challenges and Opportunities.

Applied sciences (Basel, Switzerland)·2024
Same author

Co-emulsified Alginate-Eudragit Nanoparticles: Potential Carriers for Localized and Time-defined Release of Tenofovir in the Female Genital Tract.

AAPS PharmSciTech·2024
Same author

Advances in Stimuli-responsive Hydrogels for Tissue Engineering and Regenerative Medicine Applications: A Review Towards Improving Structural Design for 3D Printing.

Current pharmaceutical design·2023
Same journal

RETRACTED: Atta et al. Effect of Montmorillonite Nanogel Composite Fillers on the Protection Performance of Epoxy Coatings on Steel Pipelines. <i>Molecules</i> 2017, <i>22</i>, 905.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Chen et al. Chemical Composition of <i>Litsea pungens</i> Essential Oil and Its Potential Antioxidant and Antimicrobial Activities. <i>Molecules</i> 2023, <i>28</i>, 6835.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Ruan et al. Comparison of Extraction, Isolation, Purification, Structural Characterization and Immunomodulatory Activity of Polysaccharides from Two Species of <i>Cistanche</i>. <i>Molecules</i> 2025, <i>30</i>, 4754.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Li et al. Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. <i>Molecules</i> 2022, <i>27</i>, 6311.

Molecules (Basel, Switzerland)·2026
Same journal

Correction: Zueva et al. Steady-State Kinetics of Enzyme-Catalyzed Hydrolysis of Echothiophate, a P-S Bonded Organophosphorus as Monitored by Spectrofluorimetry. <i>Molecules</i> 2020, <i>25</i>, 1371.

Molecules (Basel, Switzerland)·2026
Same journal

1,4-Diazatriphenylene and Its Hetero-Fused Analogs: Synthesis and Applications.

Molecules (Basel, Switzerland)·2026
See all related articles

Related Experiment Video

Updated: Mar 11, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.5K

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering.

Pariksha J Kondiah1, Yahya E Choonara2, Pierre P D Kondiah3

  • 1Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa. 549348@students.wits.ac.za.

Molecules (Basel, Switzerland)
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

Stimuli-responsive polymers and thermo-responsive hydrogels are key for injectable drug delivery and bone tissue engineering. These advanced biomaterials enhance cell response and mimic the extracellular matrix for minimally invasive therapies.

Keywords:
biodegradabledrug deliveryhydrogelsstimuli-responsivethermo-responsive polymerstissue engineering

More Related Videos

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.0K
The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

8.8K

Related Experiment Videos

Last Updated: Mar 11, 2026

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering
12:22

Synthesis of Thermogelling PolyN-isopropylacrylamide-graft-chondroitin Sulfate Composites with Alginate Microparticles for Tissue Engineering

Published on: October 26, 2016

12.5K
Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
09:39

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications

Published on: February 7, 2021

9.0K
The Quantification of Injectability by Mechanical Testing
04:46

The Quantification of Injectability by Mechanical Testing

Published on: May 13, 2020

8.8K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Regenerative Medicine

Background:

  • Biodegradable, stimuli-responsive polymers are crucial for advanced drug delivery and injectable biomaterials, particularly in bone tissue engineering.
  • Thermo-responsive hydrogels offer homogenous, water-based systems for encapsulating and delivering therapeutic agents minimally invasively.
  • Injectable therapies excel at targeting complex defect sites regardless of geometry, simplifying treatment procedures.

Purpose of the Study:

  • To review current research on stimuli-responsive hydrogel delivery systems for bone tissue engineering.
  • To highlight the advantages of injectable therapies for targeted drug delivery and tissue regeneration.
  • To explore future research directions for enhancing polymer biocompatibility and mechanical properties.

Main Methods:

  • Review of current scientific literature and research strategies.
  • Analysis of material testing data on stimuli-responsive hydrogel properties.
  • Evaluation of proposed future perspective studies in polymer modification.

Main Results:

  • Stimuli-responsive hydrogel systems demonstrate enhanced cellular responses and distribution before gelation.
  • The hydrated nature of hydrogels effectively simulates the extracellular matrix (ECM) structure.
  • Thermo-responsive hydrogels are a significant focus for bone tissue engineering applications.

Conclusions:

  • Injectable, stimuli-responsive hydrogels are promising for bone tissue engineering and drug delivery.
  • Optimizing polymer biocompatibility and mechanical properties is essential for future advancements.
  • Further research into modified natural and synthetic polymers will improve therapeutic efficacy.