Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

10.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
10.5K
The Retina01:32

The Retina

78.1K
The retina is a layer of nervous tissue at the back of the eye that transduces light into neural signals. This process, called phototransduction, is carried out by rod and cone photoreceptor cells in the back of the retina.
78.1K
Anatomy of the Eyeball01:20

Anatomy of the Eyeball

11.1K
The eye is a spherical, hollow structure composed of three tissue layers. The outer layer — the fibrous tunic, comprises the sclera — a white structure — and the cornea, which is transparent. The sclera encompasses some of the ocular surface, most of which is not visible. However, the 'white of the eye' is distinctively visible in humans compared to other species. The cornea, a clear covering at the front of the eye, enables light penetration. The eye's middle...
11.1K
Role of Skin in Vitamin D Synthesis01:23

Role of Skin in Vitamin D Synthesis

8.5K
The skin plays a crucial role in the synthesis of vitamin D, a vital nutrient for various physiological processes in the body. Vitamin D is unique because it can be synthesized in the skin through a series of chemical reactions triggered by exposure to ultraviolet B (UVB) radiation from sunlight.
The solar UV B rays (290-315 nm) are absorbed by the skin, and 7-dehydrocholesterol (provitamin D3) photolyzes it to previtamin D3, which undergoes a rapid transformation to vitamin...
8.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Decline in physical function and baseline depressive symptoms are associated with worsening asthma outcomes in older adults: A 12-month prospective cohort study.

Respiratory investigation·2026
Same author

Validation of a Rule-Based Automated Method for RPE Cell Detection Using Adaptive Optics Transscleral Flood Illumination.

Translational vision science & technology·2026
Same author

RPE Abnormality Is a Potential Primary Cause for Retinal Degeneration in Mucopolysaccharidosis Type VI Patients and a Rat Model.

Investigative ophthalmology & visual science·2026
Same author

Genotype-Phenotype Correlations in RPGRIP1-Associated Retinal Dystrophy in a Nationwide Japanese Cohort.

American journal of ophthalmology·2026
Same author

Prospective natural history and clinical biomarkers of EYS-associated retinopathy in the KEYS study.

Scientific reports·2026
Same author

Earlier first-time memory clinic visits during the COVID-19 pandemic: A comparison of dementia severity and caregiver burden.

Journal of family medicine and primary care·2026

Related Experiment Video

Updated: Mar 11, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
05:03

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

1.8K

Retinol Dehydrogenases Regulate Vitamin A Metabolism for Visual Function.

Bhubanananda Sahu1, Akiko Maeda2,3

  • 1Department of Ophthalmology and Visual Sciences, School of Medicine, Case Western Reserve University, Cleveland, OH 44106-4965, USA. bxs342@case.edu.

Nutrients
|November 24, 2016
PubMed
Summary

Retinol dehydrogenases (RDHs) are crucial for vision by processing vitamin A in the retina. Understanding RDH function in retinal pigmented epithelial and photoreceptor cells is key to treating inherited retinal diseases.

Keywords:
All-trans-retinolfundus albipunctatusretinaretinal pigmented epitheliumretinol dehydrogenasevisual cyclevitamin A

More Related Videos

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.6K
Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
14:32

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

14.2K

Related Experiment Videos

Last Updated: Mar 11, 2026

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
05:03

Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling

Published on: December 27, 2024

1.8K
Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions
08:18

Author Spotlight: Unraveling Vitamin A Transport Mechanisms — Linking Liver Receptors to Vision Health Through RBPR2 and RBP4 Interactions

Published on: October 4, 2024

1.6K
Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein
14:32

Real-time Analyses of Retinol Transport by the Membrane Receptor of Plasma Retinol Binding Protein

Published on: January 28, 2013

14.2K

Area of Science:

  • Biochemistry
  • Ophthalmology
  • Cell Biology

Background:

  • The visual system relies on vitamin A metabolism, specifically the conversion of all-trans-retinol to 11-cis-retinal, a process essential for retinal function.
  • The visual cycle, a series of biochemical reactions, facilitates this conversion, with Retinol Dehydrogenases (RDHs) playing a critical role.
  • RDHs are enzymes involved in key steps of the visual cycle within retinal pigmented epithelial (RPE) cells and photoreceptor cells.

Purpose of the Study:

  • To elucidate the specific functions of RDHs in the RPE and retina, particularly in rod photoreceptor cells.
  • To understand the regulatory mechanisms of RDHs in maintaining retinoid homeostasis.
  • To explore potential therapeutic strategies for retinal diseases linked to RDH dysfunction.

Main Methods:

  • Review and analysis of existing literature on RDH function in the visual cycle.
  • Examination of mouse models to understand RDH-related inherited retinal diseases.
  • Description of the biochemical reactions mediated by RDHs in different retinal cell types.

Main Results:

  • RDHs in RPE cells act as 11-cis-RDHs, converting 11-cis-retinol to 11-cis-retinal.
  • RDHs in rod photoreceptor cells function as all-trans-RDHs, reducing all-trans-retinal to all-trans-retinol.
  • Dysfunction of specific RDHs is associated with inherited retinal diseases.

Conclusions:

  • RDHs are vital for maintaining retinoid homeostasis and overall retinal health.
  • Mouse models provide valuable insights into the physiological roles of RDHs.
  • Targeting RDH function presents a promising therapeutic avenue for inherited retinal diseases.