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pH-dependent effects of bepridil on Ca2+-extrusion across rat heart sarcolemma
1Department of Pharmacology and Therapeutics, University of Groningen, The Netherlands.
Archives Internationales De Pharmacodynamie Et De Therapie
|March 1, 1989
Abstract:
The inhibition by bepridil of ATP-dependent Ca2+-uptake and Na+/Ca2+-exchange was studied in isolated rat cardiac sarcolemmal vesicles over a pH range of 6.3 to 7.8. It was found that the protonated and deprotonated species of bepridil induced the same inhibition and no activation of these two transport systems. However, the intrinsic activities of both systems appeared to be strongly dependent on the pH.