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Updated: Mar 11, 2026
13:15
Fabrication of Electrochemical-DNA Biosensors for the Reagentless Detection of Nucleic Acids, Proteins and Small Molecules
Published on: June 1, 2011
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Electrochemical Sensors for Clinic Analysis.
You Wang1, Hui Xu2, Jianming Zhang3
1State Key Laboratory of Industrial Control Technology, Institute of Advanced Process Control, Zhejiang University, Hangzhou 310027, P.R. China. king_wy@zjuem.zju.edu.cn.
Sensors (Basel, Switzerland)
|November 24, 2016
Summary
Advances in microfabrication enable fast, sensitive electrochemical sensors for clinical analysis. These miniaturized biosensors promise accessible, inexpensive devices for widespread chemical information acquisition by non-specialists.
Area of Science:
- Biomedical Engineering
- Analytical Chemistry
- Materials Science
Background:
- Modern medical diagnosis requires rapid and precise analytical tools.
- Microfabrication technology has advanced significantly, enabling novel sensor development.
- Electrochemical sensors offer high sensitivity and selectivity for clinical applications.
Approach:
- This review examines the fundamental principles of electrochemical sensor design and fabrication.
- It highlights recent research progress in applying these sensors to clinical chemical analysis.
- The review covers applications for blood gases, electrolytes, metabolites, DNA, and antibodies.
Key Points:
- Electrochemical sensors provide fast, sensitive, and selective detection of clinical analytes.
- Microfabrication is crucial for developing miniaturized and efficient sensor platforms.
- Applications span a wide range of clinically relevant biomarkers.
Conclusions:
- Miniaturized electrochemical biosensors are poised to become the foundation for future diagnostic devices.
- These devices will offer affordable and user-friendly methods for chemical analysis.
- Sophisticated analytical capabilities will become accessible to the general public and non-specialists.
Keywords:
Blood gasClinic analysisDNAElectrochemicalElectrolyteEnzyme electrodesGlucoseImmunosensorsSensorMore Related Videos
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