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Related Experiment Video

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Zinc supplementation for tinnitus.

Osmar C Person1, Maria Es Puga, Edina Mk da Silva

  • 1Medicina, Medical School, Universidade Federal de São Paulo, Rua Pedro de Toledo, 598, São Paulo, São Paulo, Brazil, 04039-001.

The Cochrane Database of Systematic Reviews
|November 24, 2016
PubMed
Summary
This summary is machine-generated.

This study found no evidence that oral zinc supplementation effectively treats tinnitus. Researchers concluded that zinc does not significantly improve tinnitus symptoms or related issues in adults.

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Area of Science:

  • Otolaryngology
  • Pharmacology
  • Clinical Trials

Background:

  • Tinnitus, the perception of sound without external stimuli, significantly impacts quality of life.
  • Existing therapies for tinnitus lack universal satisfaction.
  • Oral zinc supplementation has been proposed as a potential tinnitus management strategy due to zinc's role in auditory system physiology.

Purpose of the Study:

  • To evaluate the effectiveness and safety of oral zinc supplementation for managing tinnitus in adults.
  • To assess the impact of zinc on tinnitus severity, disability, and quality of life.

Main Methods:

  • Systematic review of randomized controlled trials comparing oral zinc supplementation with placebo in adults with tinnitus.
  • Searched multiple databases including Cochrane ENT, PubMed, EMBASE, and Web of Science.
  • Primary outcomes included tinnitus severity/disability and adverse effects; secondary outcomes covered quality of life, psychoacoustics, and psychological impact.

Main Results:

  • Three trials with 209 participants were included, all with moderate to high risk of bias.
  • No significant difference was found in tinnitus severity or disability between zinc and placebo groups.
  • No significant adverse effects were reported, but data on secondary outcomes were limited or not reported.

Conclusions:

  • Current evidence does not support the use of oral zinc supplementation for improving tinnitus symptoms in adults.
  • The included studies had limitations in design, participant criteria, and outcome measurement, precluding meta-analysis.
  • Further high-quality research is needed to definitively establish the role of zinc in tinnitus management.