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Related Experiment Video

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Author Spotlight: Exploring Photodynamic Therapy with Curcumin in a Murine Model for Oral Candidiasis
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The current treatment landscape: candidiasis.

Matteo Bassetti1, Maddalena Peghin2, Jean-Francois Timsit3

  • 1School of Medicine of the University of Udine and Santa Maria Misericordia University Hospital, Udine, Italy mattba@tin.it matteo.bassetti@asuiud.sanita.fvg.it.

The Journal of Antimicrobial Chemotherapy
|November 24, 2016
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Summary
This summary is machine-generated.

Candida infection epidemiology is shifting, with increased prevalence of Candida glabrata and Candida parapsilosis, impacting treatment. Antifungal stewardship programs are crucial for optimizing antifungal use and improving patient care.

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Area of Science:

  • Medical Mycology
  • Infectious Diseases
  • Epidemiology

Background:

  • Epidemiology of Candida species infections has evolved due to hospital factors, patient conditions, and antifungal use.
  • A notable shift from Candida albicans to Candida glabrata and Candida parapsilosis in critically ill patients has been observed.
  • Increasing antifungal resistance globally is linked to inappropriate antifungal agent use.

Purpose of the Study:

  • To analyze the changing epidemiology of Candida infections.
  • To highlight the impact of species distribution shifts on treatment strategies.
  • To emphasize the need for improved antifungal utilization and stewardship.

Main Methods:

  • Review of epidemiological data on Candida species distribution.
  • Analysis of factors influencing species prevalence, including antifungal exposure.
  • Evaluation of current and proposed management strategies for Candida infections.

Main Results:

  • A documented shift in Candida species prevalence, with increased rates of C. glabrata and C. parapsilosis.
  • Differences in antifungal susceptibility among Candida species necessitate careful treatment selection.
  • Antifungal resistance is a growing concern, exacerbated by improper drug usage.

Conclusions:

  • Optimizing Candida infection treatment requires prompt, adequate, and de-escalated antifungal therapy.
  • Antifungal stewardship programs are essential for promoting appropriate antifungal use.
  • A global cultural shift in healthcare is needed to enhance worldwide antifungal practices.