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Elevated serum YKL-40 levels in patients with Kawasaki disease
1a Department of Pediatrics , Yonsei University College of Medicine, Severance Children's Hospital , Seoul , South Korea.
Context:
YKL-40 is an inflammatory biomarker for endothelial dysfunction that may have a role in Kawasaki disease (KD).
Objectives:
We investigated the association of serum YKL-40 levels with KD and established laboratory parameters for YKL-40 levels and other inflammatory markers.
Methods:
YKL-40 levels and other inflammatory markers of 23 KD patients, 9 disease control patients and 11 age-matched healthy controls.
Results:
YKL-40 concentration in the serum of KD patients significantly increased during the acute disease phase compared with those of disease controls and healthy controls.
Conclusions:
Increased YKL-40 levels may provide a useful inflammatory marker for patients with KD.
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