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Related Experiment Video

Updated: Mar 11, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
05:30

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

Published on: October 31, 2025

346

Impaired gallbladder function in patients after total gastrectomy.

Tuula Tyrväinen1, Isto Nordback1, Jyri Toikka2

  • 1a Department of Gastroenterology and Alimentary Tract Surgery , Tampere University Hospital , Tampere , Finland.

Scandinavian Journal of Gastroenterology
|November 25, 2016
PubMed
Summary

Total gastrectomy patients show delayed gallbladder emptying, increasing gallstone risk. However, cholecystokinin (CCK) release remains normal, suggesting impaired gallbladder function rather than hormonal issues.

Keywords:
Total gastrectomycholecystokinincholescintygraphygallstones

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Last Updated: Mar 11, 2026

Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer
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Laparoscopic Radical Gastrectomy for Remnant Gastric Cancer

Published on: October 31, 2025

346

Area of Science:

  • Gastroenterology
  • Biliary tract physiology
  • Surgical oncology

Background:

  • Gallstone incidence is elevated post-total gastrectomy.
  • Gastric surgery impacts gallbladder and biliary tract function.
  • Multifactorial causes contribute to gallstone formation after gastrectomy.

Purpose of the Study:

  • Investigate gallbladder and biliary tract function post-gastrectomy.
  • Assess cholecystokinin (CCK) release in long-term survivors.
  • Determine the relationship between gastrectomy, gallbladder function, and gallstone formation.

Main Methods:

  • Cholescintigraphy used to evaluate gallbladder function.
  • CCK levels monitored after stimulation in gastrectomy patients and controls.
  • Study included 25 long-term survivors (≥5 years) of total gastrectomy for gastric carcinoma.

Main Results:

  • Gallstone formation observed in 41% of eligible gastrectomy patients.
  • Significantly delayed gallbladder emptying noted in gastrectomy patients compared to controls.
  • Elevated CCK levels at 30 minutes post-stimulation in gastrectomy patients, but no overall impairment.

Conclusions:

  • Delayed gallbladder emptying suggests impaired gallbladder function after total gastrectomy.
  • Cholecystokinin (CCK) release appears to be preserved post-gastrectomy.
  • Findings highlight potential for altered biliary dynamics and gallstone risk following gastric surgery.