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Related Concept Videos

Tissue Transplantation01:24

Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
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Kidney Transplant I: Introduction01:28

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A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
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Bone Marrow Sampling and Transplants01:22

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Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
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Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
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The TRANSPLANTEX initiative.

Seiamak Bahram1, Raphael Carapito1, Pierre-Antoine Gourraud2

  • 1LabEx TRANSPLANTEX; Laboratoire d'ImmunoRhumatologie Moléculaire, INSERM UMR_S1109, Centre de Recherche d'Immunologie et d'Hématologie, Faculté de Médecine, Fédération de Médecine Translationnelle de Strasbourg (FMTS), Université de Strasbourg, 67085 Strasbourg Cedex, France; INSERM Franco-Japanese Nextgen HLA Laboratory (FJ-HLA), Laboratoire International Associé (LIA), 67000 Strasbourg, France; Fédération Hospitalo-Universitaire, OMICARE, Centre de Recherche d'Immunologie et d'Hématologie, 67085 Strasbourg Cedex, France; Laboratoire d'Immunologie, Plateau Technique de Biologie, Pôle de Biologie, Nouvel Hôpital Civil, 67091 Strasbourg Cedex, France.

Human Immunology
|November 25, 2016
PubMed
Summary

TRANSPLANTEX researchers are identifying new non-HLA antigens and biomarkers to improve understanding and treatment of graft-versus-host disease and kidney transplant rejection.

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Area of Science:

  • Immunology
  • Genomics
  • Transplantation Science

Background:

  • The TRANSPLANTEX consortium utilizes high-throughput genomics and omics analyses to investigate donor and recipient factors in transplantation.
  • Focus areas include identifying novel non-Human Leukocyte Antigen (HLA) histocompatibility antigens and pre/post-transplant biomarkers.

Discussion:

  • Understanding these factors is crucial for elucidating the pathophysiology of graft-versus-host disease (GvHD) in hematopoietic cell transplants.
  • Investigating mechanisms underlying chronic graft rejection following kidney transplantation is another key objective.

Key Insights:

  • Discovery of novel non-HLA antigens may refine histocompatibility matching.
  • Identification of predictive biomarkers could enable earlier intervention and personalized treatment strategies.

Outlook:

  • This research aims to lead to improved therapeutics for GvHD and chronic kidney transplant rejection.
  • The program also encompasses industrial developments and educational initiatives in transplantation science.