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Identification and characterization of a serotype b-specific segment of the Haemophilus influenzae genome
1Department of Paediatrics, John Radcliffe Hospital, Oxford, Headington, United Kingdom.
Infection and Immunity
|September 1, 1989
Abstract:
Within the region of the Haemophilus influenzae serotype b genome required for capsule expression, a 4.6-kilobase segment was cloned, used as a hybridization probe, and found to be specific for serotype b strains. Deletion mutagenesis within this segment defined a locus necessary for serotype b capsule production and another involved in maintenance of wild-type colony appearance.