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Updated: Jul 11, 2026

Design of a Cyclic Pressure Bioreactor for the Ex Vivo Study of Aortic Heart Valves
Published on: August 23, 2011
Discovering and Developing Successful Cardiovascular Therapeutics: A Conversation With James N. Topper, MD, PhD
Abstract:
Dr James (also known as Jamie) N. Topper, MD, PhD, serves as Managing General Partner at Frazier Healthcare Partners, where he leads the Life Science Venture practice. In 2011, and 2016, he was named to the Midas List of leading venture capitalists, and, in 2013, he was recognized by Forbes as one of the top 10 healthcare investors. He has >25 years of experience working with entrepreneurs to found and build successful therapeutics-focused companies. Dr Topper holds a BS from the University of Michigan. He received an MD and PhD (in biophysics) from Stanford University School of Medicine. He completed postgraduate training in internal medicine and cardiovascular disease at the Brigham and Women's Hospital in Boston and is board certified in both disciplines.
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