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Insulin-induced autoimmune syndrome: A case report
Jian-Ping Chu1, Xiao-Wei Zheng2, Jie Lu1
1Department of Endocrinology, Ningbo First Hospital, Ningbo University, Ningbo, Zhejiang 315000, P.R. China.
Experimental and Therapeutic Medicine
|November 25, 2016
Summary
Insulin autoimmune syndrome (IAS) causes hypoglycemia due to insulin autoantibodies. Treatment with prednisone effectively lowered insulin levels in a patient, suggesting its therapeutic potential for this rare condition.
Area of Science:
- Endocrinology
- Immunology
Background:
- Insulin autoimmune syndrome (IAS) is a rare disorder characterized by hyperinsulinemic hypoglycemia.
- It is associated with autoantibodies against endogenous insulin, leading to elevated insulin levels and low blood glucose.
Purpose of the Study:
- To present a case of Insulin Autoimmune Syndrome (IAS).
- To discuss the diagnostic considerations and treatment efficacy of prednisone in managing IAS.
Main Methods:
- A 56-year-old male patient presented with spontaneous hypoglycemia.
- Diagnostic workup included measuring fasting insulin levels and detecting insulin autoantibodies.
- Treatment involved a 2-month course of prednisone.
Main Results:
- The patient exhibited significantly elevated fasting insulin levels (>1,000 mIU/l) and positive insulin autoantibodies.
- Following prednisone treatment for 2 months, the patient's insulin levels showed a decreasing trend.
Conclusions:
- IAS should be considered in the differential diagnosis for patients experiencing recurrent hypoglycemia.
- Prednisone demonstrated potential effectiveness in managing hypoglycemia associated with IAS.
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