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Crystalline nephropathy caused by tosufloxacin
Risa Matsubara1, Tetsuya Kibe1, Takemasa Nomura1
1Department of Pediatrics, Seirei-Mikatahara General Hospital, Hamamatsu, Shizuoka, Japan.
A pediatric patient developed acute kidney injury after tosufloxacin treatment for bronchitis. The condition, tosufloxacin crystalline nephropathy, resolved with hydration and drug cessation, highlighting a risk in children.
Area of Science:
- Nephrology
- Pharmacology
- Pediatric Medicine
Background:
- Tosufloxacin is a fluoroquinolone antibiotic used for bacterial infections.
- Acute kidney injury (AKI) is a serious complication that can arise from various causes, including drug toxicity.
- Crystalline nephropathy is a form of AKI caused by the precipitation of drugs or their metabolites in the renal tubules.
Observation:
- A 14-year-old female patient was prescribed tosufloxacin for acute bronchitis.
- Following three days of tosufloxacin treatment, the patient presented with symptoms of acute kidney injury.
- Renal ultrasound revealed enlarged kidneys without signs of hydronephrosis.
Findings:
- Urinalysis demonstrated the presence of drug crystal casts, indicative of crystalline nephropathy.
- The patient's condition was diagnosed as tosufloxacin-induced crystalline nephropathy.
- Recovery was observed with intravenous hydration and discontinuation of the antibiotic.
Implications:
- This case highlights the potential for tosufloxacin to cause crystalline nephropathy in pediatric patients.
- Healthcare providers should consider crystalline nephropathy in pediatric patients presenting with AKI after tosufloxacin use.
- Awareness of this adverse drug reaction is crucial for prompt diagnosis and management in children.
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