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Related Experiment Videos

[Brain structure and brain function in anorexia nervosa: a computerized tomography study].

J C Krieg, C Lauer, G Leinsinger

    Psychotherapie, Psychosomatik, Medizinische Psychologie
    |July 1, 1989
    PubMed
    Summary

    Brain imaging in anorexia nervosa revealed structural changes like ventricular dilatation. However, regional cerebral blood flow measurements did not show functional deficits, suggesting preserved brain function despite anorexia nervosa.

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    Dementia and geriatric cognitive disorders·2007

    Area of Science:

    • Neuroimaging
    • Neurology
    • Psychiatry

    Context:

    • Anorexia nervosa is associated with potential structural brain changes.
    • Previous studies suggest possible neurological alterations in patients with eating disorders.

    Purpose:

    • To investigate structural brain changes using cranial computed tomography (CT) in patients with anorexia nervosa.
    • To assess functional brain activity via regional cerebral blood flow (rCBF) measurements.
    • To correlate structural findings with functional data and compare them to healthy controls.

    Summary:

    • Cranial CT scans of 12 anorexia nervosa patients revealed ventricular dilatation and/or sulcal widening in most.
    • Re-examination of six patients after weight gain showed a trend towards normalization of these structural alterations.

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  • Regional cerebral blood flow (rCBF) measurements at admission and after weight gain did not differ significantly from each other or from a healthy control group.

    • Impact:

    • Despite observable structural brain abnormalities in anorexia nervosa, regional cerebral blood flow measurements indicate that brain function may be preserved.
    • This study challenges the assumption of widespread functional brain impairment in anorexia nervosa based solely on structural imaging.
    • Findings suggest that therapeutic interventions leading to weight restoration may contribute to the normalization of brain structure and function.