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Updated: Mar 11, 2026

The Goeckerman Regimen for the Treatment of Moderate to Severe Psoriasis
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Psoriasis.

Jacqueline E Greb1,2, Ari M Goldminz2, James T Elder3,4

  • 1Tufts University School of Medicine, Boston, Massachusetts, USA.

Nature Reviews. Disease Primers
|November 25, 2016
PubMed
Summary
This summary is machine-generated.

Psoriasis is a chronic immune disorder affecting skin and other body systems. Its genetic basis involves multiple genes, with treatments focusing on immune pathways, especially for moderate-to-severe cases.

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Area of Science:

  • Immunology
  • Genetics
  • Dermatology

Background:

  • Psoriasis is a chronic, immune-mediated disease with significant impacts on quality of life.
  • It has a polygenic genetic basis, with major genetic contributions from the Human Leukocyte Antigen complex and over 70 other identified loci.
  • Pathophysiology involves abnormal keratinocyte proliferation and immune cell infiltration, implicating nuclear factor-kappa B, interferon signaling, and the IL-23/IL-23 receptor pathway.

Purpose of the Study:

  • To review the genetic underpinnings of psoriasis.
  • To describe the pathophysiology involving immune system components.
  • To outline current therapeutic strategies and their limitations.

Main Methods:

  • Review of genetic studies identifying psoriasis susceptibility loci.
  • Analysis of immunological pathways involved in disease pathogenesis.
  • Summary of current treatment modalities for psoriasis.

Main Results:

  • Genetic factors, particularly within the MHC and involving IL-23 signaling, are crucial in psoriasis development.
  • Immune cells like dendritic cells and T cells play key roles in the inflammatory process.
  • Biologic therapies targeting specific mediators are effective for moderate-to-severe psoriasis, but advances for mild-to-moderate cases are limited.

Conclusions:

  • Psoriasis is a complex immune-mediated disease with a strong genetic component.
  • Understanding the IL-23 pathway and other immune mediators is key to current and future treatments.
  • Further research is needed to improve treatments for mild-to-moderate psoriasis.