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[Effect of immunocorrective agents on the production of the human immunodeficiency virus type 1 in vitro]
Enhancement of HIV-I production by immunostimulators leakadine (5 micrograms/ml) and thymosin (10 micrograms/ml) by 40 +/- 10% and a significant inhibition of HIV-I production by immunosuppressors cortisone and dexasone was demonstrated in H9 culture. HIV-I production was estimated by the number of cells expressing viral antigens on the membranes. The effect of modulation by immunocorrective agents of H9 cell sensitivity to HIV-I was found not to be associated with the effect of the drugs on CD4-receptor expression. A relationship between the immunostimulating doses of the drug and the concentration in which it enhances virus production was demonstrated. Possible mechanisms of the phenomenon are discussed.
Enhancement of HIV-I production by immunostimulators leakadine (5 micrograms/ml) and thymosin (10 micrograms/ml) by 40 +/- 10% and a significant inhibition of HIV-I production by immunosuppressors cortisone and dexasone was demonstrated in H9 culture. HIV-I production was estimated by the number of cells expressing viral antigens on the membranes. The effect of modulation by immunocorrective agents of H9 cell sensitivity to HIV-I was found not to be associated with the effect of the drugs on CD4-receptor expression. A relationship between the immunostimulating doses of the drug and the concentration in which it enhances virus production was demonstrated. Possible mechanisms of the phenomenon are discussed.