Physiopathology, clinical diagnosis, and treatment of hyponatremia

Hyponatremia is the commonest electrolyte disorder encountered in clinical practice. It develops when the mechanisms regulating water and electrolyte handling are impaired, which in many instances occur in the setting of concurrent diseases such as heart failure, liver failure, renal failure etc… Hyponatremia as an electrolyte disorder has several specificities: when profound it can be quickly fatal and when moderate it carries a high risk of mortality and morbidity, but at the same time incorrect treatment of profound hyponatremia can lead to debilitating neurological disease and it remains unclear if treatment of moderate hyponatremia is associated with a decrease in mortality and morbidity. A proper diagnosis is the keystone for an adequate treatment for hyponatremia and in the last few years many diagnosis algorithms have been developed to aid in the evaluation of the hyponatremic patient. Also because of the availability of vasopressin receptor antagonists and the advances made in the research regarding complications associated with hyponatremia treatment, new treatment recommendations have been published recently by several panels. This review will discuss the physiopathology, epidemiology, and clinical manifestations of hyponatremia and also the diagnosis and the treatment of this disorder with special emphasis on the complication from overly rapid correction of hyponatremia.