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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

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Diastolic Dysfunction and Hypertension

Wilson Nadruz1, Amil M Shah2, Scott D Solomon2

  • 1Cardiovascular Division, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA; Department of Internal Medicine, University of Campinas, Campinas, Brazil.

The Medical Clinics of North America
|November 26, 2016
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) is linked to heart failure and cardiovascular events. While hypertension is a major cause, it is unclear if lowering blood pressure improves outcomes.

Area of Science:

  • Cardiology
  • Cardiovascular Medicine
  • Hypertension Research

Background:

  • Left ventricular diastolic dysfunction (LVDD) involves impaired diastolic filling and predicts cardiovascular events and heart failure.
  • Hypertension is the primary community risk factor for LVDD, driven by hemodynamic overload and myocardial ischemia.
  • Additional factors like age, ethnicity, sodium intake, obesity, diabetes, and chronic kidney disease exacerbate LVDD in hypertensive patients.

Purpose of the Study:

  • To investigate the relationship between hypertension and left ventricular diastolic dysfunction.
  • To explore the impact of antihypertensive medications on LVDD.
  • To determine if improved LV diastolic function translates to better cardiovascular outcomes.

Main Methods:

  • Review of existing literature on LVDD and hypertension.
  • Analysis of factors contributing to LVDD in hypertensive individuals.
  • Examination of studies assessing the effects of blood pressure lowering on LV diastolic function and cardiovascular outcomes.

Main Results:

  • Hypertension is a significant risk factor for LVDD through mechanisms like overload and ischemia.
  • Various demographic and clinical factors are associated with LVDD in hypertensive patients.
  • Antihypertensive medications can improve LVDD, but their effect on cardiovascular outcomes requires further clarification.

Conclusions:

  • LVDD is a critical condition associated with hypertension and other risk factors.
  • While blood pressure management can improve LVDD, its impact on long-term cardiovascular outcomes needs more research.
  • Further studies are needed to establish the clinical benefit of improved diastolic function on cardiovascular events.

Keywords:
Diastolic dysfunctionHeart failureHypertensionLeft ventricular hypertrophy

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