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Related Experiment Video

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Assessment of Vascular Function in Patients With Chronic Kidney Disease
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The Pressure of Aging.

Majd AlGhatrif1, Mingyi Wang2, Olga V Fedorova2

  • 1Laboratory of Cardiovascular Science, NIA, NIH, Baltimore, MD, USA; Department of Medicine, Johns Hopkins Bayview Medical Center, Johns Hopkins School of Medicine, Baltimore, MD, USA.

The Medical Clinics of North America
|November 26, 2016
PubMed
Summary

Aging causes significant hemodynamic changes and hypertension. Arterial stiffening increases pulse wave velocity and pulse pressure, with salt-sensitive hypertension linked to marinobufagenin.

Keywords:
Age-dependent salt-sensitive hypertensionAgingAngiotensin IIArterial fibrosisArterial wall remodelingHemodynamicsMarinobufageninPulse wave velocity

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Pulse Wave Velocity Testing in the Baltimore Longitudinal Study of Aging
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Area of Science:

  • Cardiovascular physiology
  • Gerontology
  • Hypertension research

Background:

  • Aging significantly alters hemodynamics, contributing to widespread hypertension.
  • Central arterial property changes, including aortic distensibility and blood pressure, are key.
  • Pulse wave velocity and pulse pressure trajectories diverge in older adults.

Purpose of the Study:

  • To investigate age-related hemodynamic changes and their link to hypertension.
  • To explore the divergence in pulse wave velocity and pulse pressure with aging.
  • To examine the role of marinobufagenin in age-related salt-sensitive hypertension.

Main Methods:

  • Analysis of hemodynamic parameters in aging populations.
  • Assessment of central arterial properties such as aortic distensibility.
  • Evaluation of pulse wave velocity and pulse pressure changes over time.
  • Investigation of marinobufagenin levels in relation to salt sensitivity.

Main Results:

  • Aging leads to decreased aortic distensibility and increased diastolic blood pressure.
  • Pulse wave velocity and pulse pressure increase significantly after the sixth decade.
  • Pulse wave velocity and pulse pressure exhibit diverging trends with advanced age.
  • Marinobufagenin is implicated as a mediator in age-related salt-sensitive hypertension.

Conclusions:

  • Age-related arterial stiffening is a major driver of hemodynamic changes and hypertension.
  • The diverging paths of pulse wave velocity and pulse pressure highlight complex aging vascular dynamics.
  • Marinobufagenin represents a potential therapeutic target for managing salt-sensitive hypertension in the elderly.