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Endotoxemia accelerates diaphragm dysfunction in ventilated rabbits.

Yi Yang1, Tao Yu2, Chun Pan1

  • 1Department of Critical Care Medicine, Zhong-Da Hospital, Southeast University, Nanjing, China.

The Journal of Surgical Research
|November 26, 2016
PubMed
Summary
This summary is machine-generated.

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Sepsis significantly worsens ventilator-induced diaphragm dysfunction in rabbits. This study found that endotoxemia accelerates diaphragm damage, impairs microcirculation, and increases lipid accumulation in respiratory muscles.

Area of Science:

  • Critical Care Medicine
  • Respiratory Physiology
  • Pathophysiology

Background:

  • Mechanical ventilation is crucial for septic patients in intensive care units.
  • Ventilators can induce diaphragm dysfunction, but sepsis's role is unclear.
  • Existing evidence lacks clarity on sepsis accelerating ventilator-induced diaphragm dysfunction or affecting microcirculation.

Purpose of the Study:

  • To investigate if lipopolysaccharide (LPS)-induced endotoxemia accelerates diaphragm dysfunction in ventilated rabbits.
  • To evaluate the impact of endotoxemia on diaphragm microcirculation, lipid accumulation, and contractility.

Main Methods:

  • 25 New Zealand white rabbits were mechanically ventilated for 24 hours.
  • Groups included control, controlled mechanical ventilation (CMV), pressure support ventilation (PSV), and endotoxemic versions (CMV-LPS, PSV-LPS).
Keywords:
DiaphragmEndotoxemiaLipopolysaccharideMicrocirculationSepsis

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  • Evaluations included diaphragm contractility, microcirculation, lipid accumulation, and muscle fiber structure.

    • Main Results:

    • Endotoxemic rabbits showed severely compromised diaphragm contractility, microcirculation, and fiber structures after 24 hours compared to non-endotoxemic rabbits.
    • A significant increase in lipid accumulation was observed in both CMV and PSV groups compared to controls.
    • Endotoxemia exacerbated diaphragm dysfunction, microcirculation impairment, and lipid accumulation.

    Conclusions:

    • Endotoxemia accelerates the progression of diaphragm dysfunction in mechanically ventilated rabbits.
    • Sepsis negatively impacts diaphragm microcirculation, leading to lipid accumulation and impaired contractility.
    • Findings highlight the detrimental effects of endotoxemia on respiratory muscle function during mechanical ventilation.