Related Experiment Video

Updated: Mar 11, 2026

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies
13:37

A Mouse Tumor Model of Surgical Stress to Explore the Mechanisms of Postoperative Immunosuppression and Evaluate Novel Perioperative Immunotherapies

Published on: March 12, 2014

30.7K

Epidemiologic analysis: Prophylaxis and multidrug-resistance in surgery

H Solís-Téllez1, E E Mondragón-Pinzón2, M Ramírez-Marino3

  • 1Departamento de Cirugía Gastrointestinal, Hospital Ángeles del Pedregal, Ciudad de México, México; Departamento de Cirugía General, Universidad la Salle, Ciudad de México, México.

Revista De Gastroenterologia De Mexico
|November 26, 2016
PubMed
Abstract

Insights

Adherence to antimicrobial prophylaxis guidelines for preventing surgical site infections is inadequate, despite a single dose being effective. Multidrug-resistant infections are linked to intensive care unit admission.

Area of Science:

  • Infectious Diseases
  • Surgical Care
  • Hospital Epidemiology

Background:

  • Surgical site infection (SSI) is a postoperative complication within 30 days, characterized by purulent drainage, microbial isolation, and infection signs.
  • Understanding SSI epidemiology and prophylaxis is crucial for patient outcomes in tertiary care settings.

Purpose of the Study:

  • To investigate the epidemiologic characteristics of hospital-acquired infections.
  • To compare different prophylactic regimens in general surgery.
  • To identify factors associated with surgical site infections.

Main Methods:

  • Retrospective review of 728 general surgery patient records (2013-2014).
  • Analysis of antimicrobial prophylaxis adherence in 638 patients.
  • Evaluation of multidrug-resistant strains in 50 ICU patients.
  • Statistical analysis using Mann-Whitney U and chi-square tests.

Main Results:

  • A total of 728 procedures were analyzed, with 65.9% being elective surgeries.
  • Only 3.98% of patients adhered to recommended antimicrobial prophylaxis.
  • Multidrug-resistant bacterial strains were identified in the intensive care unit.

Conclusions:

  • A single prophylactic dose of antibiotics is effective for preventing SSIs.
  • Adherence to recommended antimicrobial prophylaxis guidelines was significantly low.
  • Nosocomial infections caused by multidrug-resistant organisms were significantly associated with ICU admission.
Keywords:
AntibioticAntibióticoCirugíaCritical patientInfección de herida quirúrgicaPaciente criticoProfilaxisProphylaxisResistanceResistenciaSurgerySurgical wound infection

More Related Videos

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations11:15

Quadruple-Checkerboard: A Modification of the Three-Dimensional Checkerboard for Studying Drug Combinations

Published on: July 24, 2021

5.6K
Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection05:32

Povidone Iodine Rectal Preparation at Time of Prostate Needle Biopsy is a Simple and Reproducible Means to Reduce Risk of Procedural Infection

Published on: September 21, 2015

34.2K

Related Concept Videos

Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.9K
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...
61
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
7.1K
Pulmonary Tuberculosis V01:28

Pulmonary Tuberculosis V

Medical management of tuberculosis (TB) patients involves a comprehensive approach that includes diagnosis, treatment, and monitoring. The specific strategies can vary depending on the type of tuberculosis (latent or active), the patient's overall health status, and other considerations.
Latent tuberculosis infection occurs when TB bacteria are present in a person's body, but are not causing illness or symptoms. It is not contagious, and preventive treatment is crucial to avoid the...
726
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
6.3K
Cardiomyopathy VII: Pre and Post Operative Nursing Management01:28

Cardiomyopathy VII: Pre and Post Operative Nursing Management

Patients with hypertrophic cardiomyopathy (HCM) and left ventricular outflow tract (LVOT) obstruction who remain symptomatic despite optimal medical therapy may undergo a septal myectomy (Morrow procedure). This procedure involves excising a portion of the hypertrophied septum below the aortic valve using a heart-lung machine to improve blood flow through the LVOT. Effective preoperative and postoperative nursing management ensures successful patient outcomes, minimizes complications, and...
410