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Interleukin-1 beta inhibits acetylcholine synthesis in the pituitary corticotropic cell line AtT20
P Carmeliet1, J Van Damme, C Denef
1Laboratory of Cell Pharmacology, School of Medicine, Rega Institute for Medical Research, Leuven, Belgium.
Brain Research
|July 3, 1989
Abstract:
Pituitary corticotropic AtT20 cells were found to synthesize [3H]acetylcholine, when they were incubated with [3H]choline. Treatment of the cells with picomolar concentrations of human interleukin-1 beta inhibited [3H]acetylcholine production. This effect was specific, since two antisera, directed against human interleukin-1 beta neutralized the inhibitory action of interleukin-1 beta. A possible implication of the inhibitory action of interleukin-1 on acetylcholine production in neuronal transmission disorders is discussed.