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Related Experiment Video

Updated: Mar 11, 2026

Creation of Two Saccular Elastase-Digested Aneurysms with Different Hemodynamics in One Rabbit

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Published on: April 15, 2021

Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model.

R Fahed¹, T E Darsaut², I Salazkin¹

¹From the Centre Hospitalier de l'Université de Montréal (R.F., I.S., J.R.), Interventional Neuroradiology Research Laboratory, Notre-Dame Hospital, Montreal, Quebec, Canada.

AJNR. American Journal of Neuroradiology

|November 26, 2016

Summary

This summary is machine-generated.

Researchers developed a more challenging rabbit aneurysm model for testing neurovascular devices. This new fusiform aneurysm model, unlike the standard saccular type, proved more difficult for devices to occlude, aiding device discrimination.

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Area of Science:

Biomedical Engineering
Vascular Surgery
Preclinical Research

Background:

Rabbit elastase-induced saccular aneurysms are standard for preclinical endovascular device testing.
Existing models do not adequately differentiate neurovascular devices of varying efficacies.
A need exists for a more challenging aneurysm model.

Purpose of the Study:

To develop and validate a more challenging rabbit aneurysm model.
To create complex fusiform aneurysms for advanced device testing.
To discriminate between neurovascular devices with different performance characteristics.

Main Methods:

Surgical approach involving elastase infusion and balloon dilation to create aneurysms in rabbits.
Comparison of complex fusiform aneurysms with standard saccular aneurysms.
Randomized treatment allocation to flow diversion, high-porosity stents, or control groups.
Angiographic and pathological assessment at 3 months post-treatment.

Main Results:

Successful creation of complex fusiform aneurysms in 12/16 rabbits and saccular aneurysms in 13/15.
Flow diverters achieved complete occlusion in all treated saccular and fusiform aneurysms.
High-porosity stents showed lower occlusion rates in complex fusiform aneurysms compared to saccular ones.
Pathological analysis revealed similar untreated aneurysm wall characteristics and complete neointimal coverage upon successful occlusion.

Conclusions:

A modified elastase method can successfully create challenging fusiform aneurysms in rabbits.
This novel model effectively differentiates the performance of neurovascular devices.
The complex fusiform aneurysm model offers a more rigorous preclinical testing platform.