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CONSTANCES: a general prospective population-based cohort for occupational and environmental epidemiology: cohort
Marcel Goldberg1,2, Matthieu Carton1, Alexis Descatha1,3
1Population-based Epidemiological Cohorts Unit, INSERM UMS 11, Villejuif, France.
Abstract:
WHY THE COHORT WAS SET UP?: CONSTANCES is a general-purpose cohort with a focus on occupational and environmental factors.
Cohort Participants:
CONSTANCES was designed as a randomly selected sample of French adults aged 18-69 years at inception; 200 000 participants will be included.
Data Collection Phases:
At enrolment, the participants are invited to complete questionnaires and to attend a health screening centre (HSC) for a health examination. A biobank will be set up. The follow-up includes an yearly self-administered questionnaire, a periodic visit to an HSC and linkage to social and national health administrative databases.
Main Types Of Data Collected:
Data collected for participants include social and demographic characteristics, socioeconomic status, life events and behaviours. Regarding occupational and environmental factors, a wealth of data on organisational, chemical, biological, biomechanical and psychosocial lifelong exposure, as well as residential characteristics, are collected at enrolment and during follow-up. The health data cover a wide spectrum: self-reported health scales, reported prevalent and incident diseases, long-term chronic diseases and hospitalisations, sick-leaves, handicaps, limitations, disabilities and injuries, healthcare usage and services provided, and causes of death.
Control Of Selection Effects:
To take into account non-participation and attrition, a random cohort of non-participants was set up and will be followed through the same national databases as participants.
Data Access:
Inclusions begun at the end of 2012 and more than 110 000 participants were already included by September 2016. Several projects on occupational and environmental risks already applied to a public call for nested research projects.
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