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A consensus statement on the gender perspective in lung cancer
1Medical Oncology Department, Lozano Blesa Clinical University Hospital, Avda. San Juan Bosco 15, 50009, Zaragoza, Spain. lola.isla@gmail.com.
Summary
Lung cancer incidence is rising in women, even non-smokers, with earlier diagnoses. This review covers epidemiological, biological, and therapeutic aspects specific to women with lung cancer.
Area of Science:
- Oncology
- Epidemiology
- Genetics
Background:
- Lung cancer is a leading global cause of mortality.
- Increasing incidence and earlier diagnosis observed in women compared to men.
- Smoking is a key factor, but non-smoking-related causes are also significant in women.
Purpose of the Study:
- To review current evidence on lung cancer specifically in women.
- To explore epidemiological, biological, diagnostic, and therapeutic differences.
- To address social and psychological aspects relevant to female lung cancer patients.
Main Methods:
- Consensus statement based on available evidence review.
- Analysis of epidemiological trends in lung cancer among women.
- Examination of genetic predisposition, tumor histology, and molecular profiles.
Main Results:
- Lung cancer incidence is increasing in women, often at younger ages.
- Factors beyond smoking, including genetic predisposition and molecular profiles, contribute to lung cancer in women.
- A higher proportion of women with lung cancer have EGFR gene mutations compared to men.
Conclusions:
- Lung cancer presents unique challenges and characteristics in women.
- Further research into non-smoking-related risk factors and targeted therapies is warranted.
- A comprehensive approach addressing biological and psychosocial factors is crucial for managing lung cancer in women.
