Miokamycin and leukocyte activity in man
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F Fraschini1, F Scaglione, F Ferrara
1Department of Pharmacology, Chemotherapy and Toxicology, University of Milan, Italy.
Chemotherapy
|January 1, 1989
Abstract:
The effects of miokamycin on the immune system were studied in healthy volunteers by means of the following assays: phagocytosis, intracellular killing and natural killer activity. The tests were performed before, 2 and 6 h after oral administration of 600 mg of miokamycin. The findings suggest that miokamycin stimulates phagocytosis and intracellular killing. These effects could be clearly shown 2 h after drug intake and disappeared at the 6th hour. On the contrary, the natural killer activity was not significantly stimulated by miokamycin.