Insulin pump failures in Italian children with Type 1 diabetes: retrospective 1-year cohort study

I Rabbone1, N Minuto2, R Bonfanti3

  • 1Department of Paediatrics, University of Turin, Turin, Italy.

Insights

Insulin pump failures in children and adolescents with Type 1 diabetes are common, with higher rates in advanced insulin pump models. Replacements were analyzed across various pump types in a large Italian cohort.

Area of Science:

  • Pediatric Endocrinology
  • Diabetes Technology
  • Medical Device Performance

Background:

  • Insulin pump therapy is crucial for managing Type 1 diabetes in pediatric populations.
  • The frequency and reasons for insulin pump failure and replacement require further investigation.

Purpose of the Study:

  • To evaluate insulin pump replacement rates and reasons in children and adolescents with Type 1 diabetes.
  • To identify specific insulin pump models with higher failure or malfunction rates.

Main Methods:

  • A retrospective analysis of data from 40 Italian pediatric centers was conducted.
  • Data included patient demographics, diabetes duration, and insulin pump model and replacement information for 2013.
  • 1574 children and adolescents using insulin pumps were analyzed.

Main Results:

  • The overall insulin pump replacement rate was 0.165 per patient-year.
  • Pump failure/malfunction accounted for 11.8% of replacements, and accidental damage for 4.7%.
  • Animas VIBE™ (22.1%) and Medtronic MiniMed VEO™ (17.7%) were the most frequently replaced models.

Conclusions:

  • Insulin pump failure and replacement rates in this cohort are consistent with previous reports.
  • More sophisticated insulin pump models demonstrated higher replacement rates.
  • Understanding these trends is vital for optimizing diabetes management technology.
Abstract

Related Concept Videos

Insulin Secretory Vesicles01:05

Insulin Secretory Vesicles

Insulin secretory vesicles release insulin to stimulate blood glucose uptake and regulate carbohydrate metabolism. When the blood glucose levels increase, glucose enters the pancreatic β-islet cells through glucose transporters. Once inside, glucose is metabolized through glycolysis, the citric acid cycle, and the electron transport chain, producing ATP. This increase in ATP concentration closes ATP-sensitive potassium channels, leading to depolarization of the membrane and the opening of...
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
Type I Diabetes I: Introduction01:12

Type I Diabetes I: Introduction

Type 1 diabetes mellitus is a chronic metabolic disorder characterized by an absolute deficiency of insulin resulting from the autoimmune destruction of pancreatic β-cells. Although it can occur at any age, it is most commonly diagnosed in childhood, adolescence, or early adulthood. The loss of insulin production impairs cellular glucose uptake, resulting in persistent hyperglycemia and necessitating lifelong insulin therapy.Autoimmune Destruction of β-CellsThe hallmark of type 1 diabetes is an...
Type I Diabetes II: Pathophysiology01:26

Type I Diabetes II: Pathophysiology

Type 1 diabetes mellitus arises from an immune-mediated destruction of pancreatic β-cells, resulting in an absolute deficiency of insulin. This process develops in genetically susceptible individuals when autoimmunity, environmental exposures, and immunologic dysregulation converge to trigger a targeted attack on the insulin-producing cells of the pancreas. The β-cells are located within the islets of Langerhans and are essential for regulating blood glucose by facilitating cellular uptake of...
Type I Diabetes III: Clinical Manifestations01:19

Type I Diabetes III: Clinical Manifestations

Type 1 diabetes mellitus typically presents with rapid-onset symptoms due to the body’s inability to utilize glucose in the absence of insulin. Since insulin is required for glucose uptake into cells, its deficiency leads to hyperglycemia and cellular energy deprivation, resulting in characteristic clinical features.Polyuria and PolydipsiaOne of the earliest, most prominent symptoms is polyuria (excessive urination). When blood glucose concentrations rise above the renal threshold, the kidneys...