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Related Concept Videos

Pulse01:16

Pulse

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When the heart pumps blood out, arterial elastic fibers play a crucial role in sustaining a high-pressure gradient. They expand to accommodate the received blood and then recoil - a process known as the pulse that can be either manually palpated or electronically quantified. Despite a reduction in its effect with increased distance from the heart, elements of the pulse's systolic and diastolic components persist, observable even at the arteriole level.
The pulse serves as a clinical...
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Assessing blood pressure is a standard procedure executed in virtually all medical environments. The method utilized today was established over a hundred years ago by an innovative Russian doctor, Dr. Nikolai Korotkoff. The soft ticking noise, known as Korotkoff sounds, heard while taking blood pressure readings results from turbulent blood flow within the vessels. The apparatus required for this procedure includes a sphygmomanometer, a blood pressure cuff attached to a gauge, and a...
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Pulse amplitude and quality01:17

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Pulse amplitude is a crucial indicator of cardiac health because it provides valuable insights into the strength of left ventricular contractions and the overall uniformity of blood circulation within the vasculature. The strength of the pulse is directly related to the force with which the heart contracts and the volume of blood being pumped.
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Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

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Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
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Related Experiment Video

Updated: Mar 11, 2026

Insertion, Maintenance, and Removal of the Percutaneous Dual Lumen Cannula Right Ventricular Assist Device
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Arterial pulsatility under phasic left ventricular assist device support.

Selim Bozkurt1, Sjoerd van Tuijl2, Frans N van de Vosse1

  • 1Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.

Bio-Medical Materials and Engineering
|November 26, 2016
PubMed
Summary

Phasic Continuous Flow Left Ventricular Assist Device (CF-LVAD) support can increase arterial pulsatility when synchronized with peak systole. Adjusting pump flow timing with CF-LVAD support offers control over arterial pulse pressure.

Keywords:
CF-LVADphasic CF-LVAD supportpulsatilityvarying speed

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Area of Science:

  • Cardiovascular Engineering
  • Biomedical Engineering
  • Medical Devices

Background:

  • Continuous Flow Left Ventricular Assist Devices (CF-LVADs) are crucial for heart failure management.
  • Optimizing CF-LVAD support to improve hemodyamics and patient outcomes is an ongoing research area.
  • Understanding the impact of pump timing on arterial pulsatility is essential for device development.

Purpose of the Study:

  • To investigate the effect of phasic CF-LVAD support on arterial pulsatility.
  • To determine the optimal timing for peak pump flow to maximize arterial pulsatility.
  • To explore the potential for CF-LVADs to modulate arterial pulse pressure.

Main Methods:

  • Utilized an ex-vivo experimental platform with a Micromed DeBakey CF-LVAD.
  • Phasic support was applied by phase-shifting pump control over the cardiac cycle in 0.05s increments.
  • Pump flow rate was the control variable, synchronized with a reference model for pulsatile speed.

Main Results:

  • Peak arterial pulse pressure (9 mmHg) occurred when peak pump flow coincided with peak systole.
  • Lowest arterial pulse pressure (2 mmHg) was observed when peak pump flow was applied during diastole.
  • Arterial pulsatility varied significantly based on the phase-shifting of pump flow, while mean pressures remained constant.

Conclusions:

  • Synchronizing CF-LVAD speed with peak systole is recommended to enhance arterial pulsatility.
  • Phasic CF-LVAD support offers a method to modulate arterial pulsatility.
  • Counter-pulsating CF-LVAD support can be employed to decrease arterial pulsatility.