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Epigenetic Impact on EBV Associated B-Cell Lymphomagenesis
Shatadru Ghosh Roy1, Erle S Robertson2, Abhik Saha3
1Department of Life Sciences, Presidency University, 86/1, College Street, Kolkata 700073, West Bengal, India. shatadru54@gmail.com.
Biomolecules
|November 26, 2016
Summary
Epigenetic changes in Epstein-Barr virus (EBV)-associated cancers alter gene expression. Understanding these epigenetic modifications in EBV-induced lymphomas may reveal new therapeutic targets.
Area of Science:
- Oncology
- Virology
- Epigenetics
Background:
- Epigenetic modifications are crucial in human cancer development.
- Approximately 20% of human cancers are linked to tumor viruses.
- Epstein-Barr virus (EBV) is the first identified human tumor virus, frequently associated with epigenetic alterations in cancers.
Purpose of the Study:
- To elucidate the epigenetic consequences of EBV-host interactions in EBV-induced B-cell lymphomas.
- To explore how EBV influences host cell epigenetics and vice versa.
- To identify potential novel therapeutic strategies targeting epigenetic alterations in EBV-associated cancers.
Main Methods:
- This review synthesizes existing research on EBV and epigenetic modifications.
- It examines how EBV oncoproteins interact with cellular epigenetic machinery.
- The review analyzes epigenetic changes in both viral and host genomes in EBV-associated cancers.
Main Results:
- EBV induces significant epigenetic alterations in both viral and host genomes.
- Cell type-specific EBV latent gene expression is regulated by cellular epigenetic machinery.
- EBV oncoproteins recruit epigenetic regulators to deregulate host gene expression, contributing to cancer development.
Conclusions:
- EBV-host interactions lead to profound epigenetic changes in B-cell lymphomas.
- Targeting reversible epigenetic marks presents a promising avenue for novel cancer therapies.
- Further research into these epigenetic mechanisms could lead to effective treatments for EBV-associated B-cell lymphomas.
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