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Updated: Mar 11, 2026
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Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
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Palladium-mediated in situ synthesis of an anticancer agent
Eugenio Indrigo1, Jessica Clavadetscher1, Sunay V Chankeshwara1
1EaStCHEM School of Chemistry, University of Edinburgh, David Brewster Road, EH9 3FJ Edinburgh, UK. Mark.Bradley@ed.ac.uk.
Chemical Communications (Cambridge, England)
|November 26, 2016
Abstract:
As a novel prodrug activation strategy Pd(0) nanoparticles, entrapped within a modular polymeric support, were used in cell culture, to synthesise the anticancer agent PP-121 from two non-toxic precursors, thereby inducing cell death in the first example of in situ mediated drug synthesis.
