Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fluoxetine overdose in an adolescent.

M A Riddle, N Brown, D Dzubinski

    Journal of the American Academy of Child and Adolescent Psychiatry
    |July 1, 1989
    PubMed
    Summary

    A 13-year-old boy experienced seizures and EKG changes after a large fluoxetine overdose. Symptoms resolved spontaneously, indicating fluoxetine can be managed effectively in adolescents.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Efficacy of a stabilized liquid potassium sorbate preservative to prevent bacterial proliferation in bovine colostrum and milk.

    Journal of dairy science·2025
    Same author

    Impact of the Covid pandemic on health care equity in NHS General Dental Practice.

    Community dental health·2022
    Same author

    Demand for regional level III neonatal services is not reduced during national COVID lockdowns.

    Early human development·2021
    Same author

    Findings in 1,123 Men with Preoperative <sup>68</sup>Ga-Prostate-Specific Membrane Antigen Positron Emission Tomography/Computerized Tomography and Multiparametric Magnetic Resonance Imaging Compared to Totally Embedded Radical Prostatectomy Histopathology: Implications for the Diagnosis and Management of Prostate Cancer.

    The Journal of urology·2021
    Same author

    The impact of signposting and group support pathways on a community-based physical activity intervention grounded in motivational interviewing.

    Journal of public health (Oxford, England)·2021
    Same author

    Relationships between nitrogen cycling microbial community abundance and composition reveal the indirect effect of soil pH on oak decline.

    The ISME journal·2020

    Area of Science:

    • Pharmacology
    • Toxicology
    • Pediatric Neurology

    Background:

    • Selective serotonin reuptake inhibitors (SSRIs) like fluoxetine are commonly prescribed for psychiatric conditions in adolescents.
    • Acute overdose of SSRIs can lead to various clinical manifestations, necessitating careful management.
    • Tourette's syndrome and obsessive-compulsive disorder are relevant comorbidities in pediatric psychiatric care.

    Observation:

    • A 13-year-old male with Tourette's syndrome and obsessive-compulsive disorder ingested a large quantity of fluoxetine hydrochloride.
    • The patient presented with a grand mal seizure, ST segment depression on electrocardiogram (EKG), nausea, dizziness, and headache.
    • These acute symptoms followed the significant fluoxetine ingestion.

    Findings:

    • Despite the severe presenting symptoms, including a seizure and EKG abnormalities, the overall response to fluoxetine was favorable.
    • All observed signs and symptoms, such as the seizure and cardiac changes, demonstrated spontaneous remission.
    • The patient's clinical course suggests a self-limiting nature of the overdose effects in this specific case.

    Implications:

    • This case highlights the importance of monitoring for specific adverse events following large fluoxetine ingestions in pediatric patients.
    • The spontaneous resolution of symptoms underscores the potential for conservative management in select cases of acute fluoxetine overdose.
    • Understanding the toxicokinetics and clinical effects of fluoxetine in adolescents is crucial for effective emergency care and treatment planning.

    Related Experiment Videos