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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Divergent Total Synthesis of Atisane-Type Diterpenoids
Guili Zhu1, Sachin B Wadavrao1, Bo Liu1,2
1Key Laboratory of Green Chemistry & Technology of the Ministry of Education, College of Chemistry, Sichuan University, No. 29 Wangjiang Road, Chengdu, Sichuan, 610064, P. R. China.
Divergent total synthesis enables the creation of complex atisane-type diterpenoids from plants. This strategy uses a common intermediate for structural interconversions, yielding diverse compounds.
Area of Science:
- Organic Chemistry
- Natural Product Synthesis
- Medicinal Chemistry
Background:
- Atisane-type diterpenoids are tetracyclic C20-diterpenoids found in plants.
- These compounds exhibit structural complexity and diverse pharmacological activities.
- Their unique bicyclo[2.2.2]octane skeleton is of significant synthetic interest.
Purpose of the Study:
- To summarize the divergent total synthesis of atisane-type diterpenoids.
- To highlight the utility of divergent synthesis in accessing complex natural products.
- To showcase the structural interconversion from common intermediates.
Main Methods:
- Divergent total synthesis strategies.
- Utilizing common intermediates for structural diversification.
- Chemical synthesis and structural elucidation.
Main Results:
- Successful synthesis of multiple atisane-type diterpenoids.
- Demonstration of efficient structural interconversions.
- Access to a library of complex natural products.
Conclusions:
- Divergent total synthesis is a powerful approach for atisane-type diterpenoids.
- This strategy facilitates the exploration of structure-activity relationships.
- It provides a versatile platform for natural product synthesis.
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