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Updated: Mar 11, 2026

A Murine Model of Ischemic Retinal Injury Induced by Transient Bilateral Common Carotid Artery Occlusion
Published on: November 12, 2020
Update on the Management of Central Retinal Artery Occlusion
Michael Dattilo1, Valérie Biousse2, Nancy J Newman3
1Department of Ophthalmology, Emory University School of Medicine, 1365-B Clifton Road, Northeast, Atlanta, GA 30322, USA; Neuro-Ophthalmology, Emory Eye Center, 1365-B Clifton Road, Northeast, Atlanta, GA 30322, USA.
Insights
Central retinal artery occlusion (CRAO) is a serious eye condition. Current treatments do not improve vision, so focus is on preventing future vascular events like stroke.
Area of Science:
- Ophthalmology
- Neurology
- Vascular Medicine
Background:
- Central retinal artery occlusion (CRAO) is an ocular emergency.
- It shares significant risk factors with acute cerebral ischemia.
- Often caused by emboli from carotid arteries, aorta, or heart.
Purpose of the Study:
- To review the understanding of CRAO.
- To emphasize the importance of secondary prevention strategies.
Main Methods:
- Literature review and synthesis of existing data on CRAO.
- Analysis of risk factors and outcomes.
Main Results:
- No current therapeutic interventions improve visual outcomes in CRAO.
- Risk factors for CRAO and cerebral ischemia are nearly identical.
Conclusions:
- Management should prioritize secondary prevention of major vascular events.
- Focus on preventing stroke, heart attack, and cardiovascular death is crucial.
Abstract:
Central retinal artery occlusion (CRAO) is caused by partial or complete occlusion of the central retinal artery, most commonly by an embolus from the ipsilateral carotid artery, aortic arch, or heart, and is the ocular equivalent of an acute cerebral ischemic event. The risk factors for a CRAO and acute cerebral ischemia are very similar, if not identical. Because no current therapeutic intervention has been shown to improve visual outcomes compared with the natural history of CRAO, management of CRAO should be focused on secondary prevention of vascular events, such as cerebral ischemia, myocardial infarction, and cardiovascular death.
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