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What We Can Learn from "Super-responders".

Alessandro Proclemer1, Daniele Muser2, Domenico Facchin1

  • 1University Hospital Santa Maria della Misericordia, Udine 33100, Italy.

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|November 26, 2016
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Summary
This summary is machine-generated.

This review examines cardiac resynchronization therapy (CRT) outcomes, including mortality and defibrillator use, in patients with preserved left ventricular ejection fraction. It considers the need for defibrillator backup in super-responders with normalized heart function.

Keywords:
CRTCardiac resynchronization therapyLeft ventricular ejection fractionLeft ventricular function

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Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
  • Patient selection for CRT typically focuses on reduced left ventricular ejection fraction.
  • The outcomes of CRT in patients with preserved ejection fraction require further investigation.

Purpose of the Study:

  • To review current knowledge on CRT decision-making for patients with preserved ejection fraction.
  • To analyze long-term mortality, sudden death, and CRT-defibrillator interventions.
  • To assess echocardiographic changes and the need for defibrillator backup in super-responders.

Main Methods:

  • Literature review of studies on cardiac resynchronization therapy.
  • Analysis of long-term outcomes including total and cardiac mortality.
  • Evaluation of echocardiographic parameters and device intervention rates.

Main Results:

  • Data on long-term outcomes in patients with preserved ejection fraction undergoing CRT is presented.
  • The role of defibrillator backup in super-responders with normalized left ventricular function is discussed.
  • Evolving echocardiographic parameters post-CRT implantation are analyzed.

Conclusions:

  • CRT may offer benefits beyond traditional indications, even in patients with preserved ejection fraction.
  • Careful consideration of defibrillator backup is needed for super-responders.
  • Further research is warranted to optimize CRT selection and management.