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What We Can Learn from "Super-responders"

Alessandro Proclemer1, Daniele Muser2, Domenico Facchin1

  • 1University Hospital Santa Maria della Misericordia, Udine 33100, Italy.

Heart Failure Clinics
|November 26, 2016
PubMed

Insights

This review examines cardiac resynchronization therapy (CRT) outcomes, including mortality and defibrillator use, in patients with preserved left ventricular ejection fraction. It considers the need for defibrillator backup in super-responders with normalized heart function.

Area of Science:

  • Cardiology
  • Cardiac Electrophysiology
  • Heart Failure Management

Background:

  • Cardiac resynchronization therapy (CRT) is a treatment for heart failure.
  • Patient selection for CRT typically focuses on reduced left ventricular ejection fraction.
  • The outcomes of CRT in patients with preserved ejection fraction require further investigation.

Purpose of the Study:

  • To review current knowledge on CRT decision-making for patients with preserved ejection fraction.
  • To analyze long-term mortality, sudden death, and CRT-defibrillator interventions.
  • To assess echocardiographic changes and the need for defibrillator backup in super-responders.

Main Methods:

  • Literature review of studies on cardiac resynchronization therapy.
  • Analysis of long-term outcomes including total and cardiac mortality.
  • Evaluation of echocardiographic parameters and device intervention rates.

Main Results:

  • Data on long-term outcomes in patients with preserved ejection fraction undergoing CRT is presented.
  • The role of defibrillator backup in super-responders with normalized left ventricular function is discussed.
  • Evolving echocardiographic parameters post-CRT implantation are analyzed.

Conclusions:

  • CRT may offer benefits beyond traditional indications, even in patients with preserved ejection fraction.
  • Careful consideration of defibrillator backup is needed for super-responders.
  • Further research is warranted to optimize CRT selection and management.

Keywords:
CRTCardiac resynchronization therapyLeft ventricular ejection fractionLeft ventricular function

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