Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hereditary vestibulo-cochlear dysfunction and vascular disorders.

W I Verhagen1, P L Huygen, E J Theunissen

  • 1Department of Neurology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.

Journal of the Neurological Sciences
|August 1, 1989
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[From gene to disease; non-syndromic, autosomal dominant, low-frequency sensorineural hearing loss (DFNA6/14)].

Nederlands tijdschrift voor geneeskunde·2003
Same author

Hereditary cochleovestibular dysfunction due to a COCH gene mutation (DFNA9): a follow-up study of a family.

Clinical otolaryngology and allied sciences·2002
Same author

Fluctuant, progressive hearing loss associated with Menière like vertigo in three patients with the Pendred syndrome.

International journal of pediatric otorhinolaryngology·2001
Same author

Progressive fluctuant hearing loss, enlarged vestibular aqueduct, and cochlear hypoplasia in branchio-oto-renal syndrome.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·2001
Same author

The DFNA10 phenotype.

The Annals of otology, rhinology, and laryngology·2001
Same author

A Dutch family with progressive autosomal dominant non-syndromic sensorineural hearing impairment linked to DFNA13.

Clinical otolaryngology and allied sciences·2001

A rare genetic condition causes progressive hearing loss and Dandy syndrome in a family, characterized by Dandy syndrome and oscillopsia. This autosomal dominant disorder appears linked to vascular issues, not typical neurological or ototoxic causes.

Area of Science:

  • Neuroscience
  • Genetics
  • Ophthalmology

Background:

  • Progressive autosomal dominant vestibulocochlear dysfunction can lead to significant neurological and auditory impairment.
  • Dandy syndrome, characterized by oscillopsia (visual disturbance) dependent on head movements, presents a diagnostic challenge.

Observation:

  • A family exhibited a unique progressive vestibulocochlear disorder.
  • Affected individuals presented with Dandy syndrome and sensorineural hearing loss.
  • No history of infectious diseases, neurological disorders, or ototoxic drug use was reported.

Findings:

  • The family's condition followed an autosomal dominant inheritance pattern.
  • A high incidence of vascular disorders, including hypertension, stroke, and myocardial infarction, was noted within the family.

Related Experiment Videos

  • The vestibulocochlear dysfunction was progressive and linked to head movement-induced oscillopsia.

    • Implications:

    • This case highlights a potential genetic link between vestibulocochlear dysfunction, Dandy syndrome, and vascular disorders.
    • Understanding this genetic etiology may inform future diagnostic and therapeutic strategies for similar conditions.
    • Further research is warranted to elucidate the specific genetic mechanisms and their interaction with vascular health.