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Morphological and functional imaging of neck paragangliomas
J-P Guichard1, N Fakhry2, J Franc1
1Department of Neurovascular Imaging, H"pital LariboisiSre, AP-HP, Universit, Paris 7 Denis Diderot, 75010 Paris, France.
European Annals of Otorhinolaryngology, Head and Neck Diseases
|November 27, 2016
Summary
Optimal imaging techniques for neck paragangliomas (PGL) involve both morphological and functional modalities. 68Gallium-labelled DOTA peptides PET imaging is now the preferred method for evaluating cervical PGL.
Area of Science:
- Oncology
- Radiology
- Endocrinology
Background:
- Neck paragangliomas (PGL) are rare, hypervascular tumors originating from paraganglionic tissue.
- Common sites include the carotid bifurcation (carotid body) and along the vagus nerve.
Purpose of the Study:
- To review optimal techniques for localization and characterization of neck paragangliomas (PGL).
- To highlight advancements in imaging modalities for accurate diagnosis and staging.
Main Methods:
- Systematic literature review of studies indexed in PubMed/Medline.
- Analysis of morphological and functional imaging techniques.
Main Results:
- MR angiography is the preferred noninvasive technique for diagnosis and staging.
- CT angiography is a viable alternative.
- Functional imaging, particularly 68Gallium-labelled DOTA peptides PET, is now the first-line modality for evaluating cervical PGL, regardless of genetic background.
- Somatostatin receptor scintigraphy (SRS) was previously the reference for sporadic PGL staging.
Conclusions:
- Morphological and functional imaging are crucial for accurate staging of neck PGL.
- Advanced PET tracers like 68Gallium-labelled DOTA peptides have become indispensable in the evaluation of cervical PGL.
