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Updated: Mar 11, 2026
Visualization and Quantitative Analysis of Embryonic Angiogenesis in Xenopus tropicalis
Published on: May 25, 2017
Vertebrate embryos as tools for anti-angiogenic drug screening and function
Shaunna L Beedie1, Alexandra J Diamond2, Lucas Rosa Fraga2
1School of Medicine, Medical Sciences and Nutrition, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK; Molecular Pharmacology Section, Genitourinary Malignancies Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, USA.
None:
The development of new angiogenic inhibitors highlights a need for robust screening assays that adequately capture the complexity of vessel formation, and allow for the quantitative evaluation of the teratogenicity of new anti-angiogenic agents. This review discusses the use of screening assays in vertebrate embryos, specifically focusing upon chicken and zebrafish embryos, for the detection of anti-angiogenic agents.
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