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Related Concept Videos

Notch Signaling Pathway03:14

Notch Signaling Pathway

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The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...
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Non-Canonical Wnt Signaling Pathways01:41

Non-Canonical Wnt Signaling Pathways

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Hedgehog Signaling Pathway02:33

Hedgehog Signaling Pathway

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The Hedgehog gene (Hh) was first discovered due to its control of the growth of disorganized, hair-like bristles phenotype in Drosophila, much like hedgehog spines. Hh plays a crucial role in the development of organs and the maintenance of homeostasis in both invertebrates and vertebrates. However, while Drosophila has only one Hh protein, mammals have multiple functional Hedgehog proteins - Sonic (Shh), Desert (Dhh), and Indian Hedgehog (Ihh). All of these homologous proteins have adapted to...
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IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

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Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
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Cell Signaling Feedback Loops01:07

Cell Signaling Feedback Loops

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Positive and negative feedback loops are crucial for regulating biological signaling systems. These feedback loops are processes that connect output signals to their inputs.
Negative feedback loops
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Output limiter
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Related Experiment Video

Updated: Mar 11, 2026

A Microfluidics Approach for the Functional Investigation of Signaling Oscillations Governing Somitogenesis
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Delta-Notch signalling in segmentation.

Bo-Kai Liao1, Andrew C Oates2

  • 1Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, London NW7 1AA, UK.

Arthropod Structure & Development
|November 27, 2016
PubMed
Summary
This summary is machine-generated.

Understanding how segmented body structures form is key. This study explores the Notch signaling pathway

Keywords:
Clock and wavefront modelDelta-NotchDoppler effectPatterningSomitogenesis

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Cell Aggregation Assays to Evaluate the Binding of the Drosophila Notch with Trans-Ligands and its Inhibition by Cis-Ligands
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Area of Science:

  • Developmental biology
  • Evolutionary biology
  • Molecular signaling

Background:

  • Modular body organization and segmentation are widespread in multicellular organisms.
  • Recent findings suggest conserved segmentation mechanisms across arthropods and vertebrates.
  • The evolutionary origins of segmentation may trace back to a bilaterian ancestor.

Purpose of the Study:

  • To discuss vertebrate segmentation, focusing on the Notch intercellular signaling pathway.
  • To explore the potential roles of Notch signaling in arthropod segmentation.
  • To investigate the relationship between Notch-mediated lateral inhibition and synchronization in segmentation.

Main Methods:

  • Review of existing literature on vertebrate segmentation and Notch signaling.
  • Analysis of models for Notch pathway function in oscillator synchronization and gene expression patterns.
  • Comparative discussion of Notch signaling roles in arthropod and vertebrate segmentation.

Main Results:

  • The Notch pathway plays a crucial role in synchronizing noisy biological oscillators during segmentation.
  • Notch signaling modulates gene expression wave patterns, contributing to robust pattern formation.
  • Similarities in segmentation mechanisms suggest potential homology across annelids, arthropods, and chordates.

Conclusions:

  • The Notch pathway is a central player in the robust generation of segmented body structures.
  • Further research is needed to fully elucidate Notch signaling functions in arthropod segmentation.
  • Open questions remain regarding the evolutionary conservation and precise mechanisms of Notch in segmentation across diverse clades.